Using AI to find hidden metabolic pathways that affect diseases
Democratizing Multi-Omics to Expedite Discovery of Hidden Metabolic Pathways
This project builds AI tools to link proteins and small molecules so researchers can uncover metabolic pathways that matter for cancers, diabetes, and other diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11414811 on NIH RePORTER |
What this research studies
Researchers will combine protein and metabolite data from the same samples and feed those multi-omic datasets into artificial intelligence models that learn connections between molecules and proteins. The goal is to reduce the need for time-consuming expert interpretation so more labs can use these approaches. The team will validate that the AI can recover known links and discover new ones, using existing data and experimental follow-up. Over time the tools are meant to be easier to use so discoveries spread beyond specialist groups.
Who could benefit from this research
Good fit: People with cancer or diabetes who are willing to donate blood, tissue, or clinical data to multi-omic research would be the most relevant candidates to contribute to this work.
Not a fit: People without metabolic or cancer-related conditions, or those unwilling to provide samples or data, are unlikely to see direct benefit from participating.
Why it matters
Potential benefit: If successful, this work could speed up discovery of disease-related metabolic pathways and point to new drug targets or diagnostic tests for cancers, diabetes, and other conditions.
How similar studies have performed: Preliminary data and other published work show AI plus multi-omics can reveal known and novel metabolite-protein links, but the approach is still emerging and not yet broadly applied in clinical care.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Meyer, Jesse — Cedars-Sinai Medical Center
- Study coordinator: Meyer, Jesse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.