Using aerobic exercise to enhance mobility in people with multiple sclerosis
Official title: Aerobic exercise to improve mobility in multiple sclerosis: optimizing design and execution for a full-scale multimodal remyelination clinical trial
Funded at Oregon Health & Science University · NIH-10864030 · Data updated 2026-11-12
This study is looking at how aerobic exercise might help people with multiple sclerosis move better and repair their nerves, and it’s for anyone with MS who wants to see if exercise can make a positive difference in their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $159,729 |
| NIH project number | 5K23HD101667-05 |
| Project ID | NIH-10864030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis who experience mobility challenges.
✕Less likely to help
Patients with other neurological conditions or those who do not have mobility issues related to multiple sclerosis may not benefit from this research.
What this research studies
This research investigates how aerobic exercise can improve mobility and promote remyelination in individuals with multiple sclerosis (MS). It aims to identify the best ways to measure remyelination and assess the effectiveness of an aerobic exercise intervention. By combining rehabilitative therapies with pharmacological treatments, the study seeks to enhance the conduction of nerve signals and reduce disability associated with MS. The research will involve both animal models and human participants to establish a reliable approach for future clinical trials.
Why it matters
Potential benefit: If successful, this research could lead to improved mobility and quality of life for patients with multiple sclerosis.
How similar studies have gone: Previous research has shown that aerobic exercise can promote remyelination in animal models, indicating potential for success in human studies.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Wooliscroft, Lindsey Brianna — Oregon Health & Science University
- Study coordinator: Wooliscroft, Lindsey Brianna
Related research
Other NIH-funded projects on the same topics.
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Susceptibility-based MRI biomarkers for multiple sclerosis
A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
-
Aerobic exercise to boost stroke rehabilitation outcomes with a VR game
A VA-based study tests whether an aerobic workout before a hand-rehabilitation game can improve recovery after stroke for veterans.
-
Mediterranean-style eating and aging in people with multiple sclerosis
This project looks at whether following a Mediterranean-style diet is linked to slower biological aging and less brain shrinkage in people living with multiple sclerosis.
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Imaging brain energy use in multiple sclerosis with a new imaging method
A new MRI-based method will non-invasively measure how the brain uses glucose and ketones in people with multiple sclerosis.
-
Astrocyte exosomes as aging biomarkers and drivers of MS progression
Researchers are testing a blood-based biomarker from astrocyte-like exosomes to understand why multiple sclerosis gets worse with age and to identify potential targets for treatment.
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Community-based aerobic exercise for adults with moderate to severe traumatic brain injury
A year-long aerobic exercise program is being tested to see if it can improve thinking, mood, and quality of life for adults aged 45–80 who have had moderate to severe traumatic brain injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.