Using advanced ultrasound to study brain changes in Batten disease
High-resolution multi-modal ultrasound imaging of brain development in Batten disease models
['FUNDING_R21'] · UNIVERSITY OF ROCHESTER · NIH-10698117
This study is looking at how new ultrasound technology can help us see changes in the brains of mice with Batten disease, which could lead to better ways to understand and treat this condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10698117 on ClinicalTrials.gov |
What this research studies
This research investigates how advanced ultrasound techniques can track changes in the brain associated with Batten disease, a severe neurological disorder. By employing functional ultrasound and shear wave elastography, the study aims to create a detailed picture of brain structure and function over time. The researchers will use a mouse model of Batten disease to observe how brain connectivity changes in response to sensory stimuli, providing insights into disease progression. This approach aims to establish new biomarkers that could help in developing effective therapies for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Batten disease or those with a genetic predisposition to neurological disorders.
Not a fit: Patients with non-genetic neurological disorders or those not affected by Batten disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new biomarkers for Batten disease, facilitating the development of targeted therapies.
How similar studies have performed: While the use of advanced imaging techniques in neurological research is promising, this specific approach to studying Batten disease is novel and has not been extensively tested.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOYLEY, MARVIN M — UNIVERSITY OF ROCHESTER
- Study coordinator: DOYLEY, MARVIN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.