Using advanced statistical methods to understand the causes of Alzheimer's disease and related disorders.
Official title: Bayesian Statistical Learning for Robust and Generalizable Causal Inferences in Alzheimer Disease and Related Disorders Research
Funded at Columbia University Health Sciences · NIH-11049080 · Data updated 2026-11-12
This study is looking at how things in our environment, like air pollution and heavy metals, might affect the chances of developing Alzheimer's Disease and similar conditions over time, especially in people with health issues like high blood pressure or heart disease, and it will also create easy-to-use tools for other researchers to help them learn more about these risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $489,873 |
| NIH project number | 5R01AG077518-03 |
| Project ID | NIH-11049080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's or related disorders, particularly those exposed to environmental pollutants.
✕Less likely to help
Patients who are not at risk for Alzheimer's disease or related disorders may not benefit from this research.
What this research studies
This research aims to develop innovative statistical methods to analyze how environmental factors, such as air pollution and heavy metals, affect the risk of Alzheimer's Disease and related disorders over a person's lifetime. By studying long-term health data from diverse populations, the researchers will explore how conditions like hypertension and cardiovascular disease may influence the onset and severity of Alzheimer's. The project will also create user-friendly software tools to help other researchers apply these methods in their own studies, enhancing our understanding of Alzheimer's risk factors.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for Alzheimer's disease by identifying key environmental risk factors.
How similar studies have gone: Previous research has shown promise in using statistical methods to analyze health outcomes related to environmental exposures, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Valeri, Linda — Columbia University Health Sciences
- Study coordinator: Valeri, Linda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.