Using advanced radiation techniques to reduce lung injury in lung cancer treatment
Project 3: Carbon and Electron FLASH radiotherapy for mitigation of normal lung injury in NSCLC
This study is looking at new ways to use special types of radiation therapy to treat non-small cell lung cancer while protecting your lungs and other healthy tissues from damage, so you can have better results and a better quality of life after treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11030334 on NIH RePORTER |
What this research studies
This research investigates the use of Carbon, Proton, and Electron FLASH radiotherapy to minimize lung damage caused by radiation during the treatment of non-small cell lung cancer (NSCLC). By delivering radiation at ultra-high dose rates, the study aims to protect normal lung tissue and other organs from the harmful effects of radiation while still effectively targeting cancer cells. The research will assess the impact of these advanced radiation techniques on lung microvascular damage and inflammatory responses, providing insights into how to improve patient outcomes and quality of life after treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-small cell lung cancer who require thoracic irradiation as part of their treatment.
Not a fit: Patients with early-stage lung cancer who do not require radiation therapy or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer lung cancer treatments with fewer side effects, improving the quality of life for patients.
How similar studies have performed: Previous research has shown promising results with FLASH radiotherapy techniques, indicating potential for significant advancements in cancer treatment.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Abdollahi, Amir — University of Pennsylvania
- Study coordinator: Abdollahi, Amir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.