Using advanced MRI to understand how prostate cancer avoids the immune system
Imaging Prostate Cancer Immune Evasion using Chemical Exchange Saturation Transfer MRI
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-10759454
This study is testing a new imaging method to help doctors see how prostate cancer hides from the immune system, which could help them figure out the best immunotherapy treatments for patients like you.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10759454 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new imaging technique called Chemical Exchange Saturation Transfer MRI (CEST MRI) to visualize immune evasion in prostate cancer. By creating unique imaging agents that can be detected simultaneously, the study aims to identify biomarkers that indicate how well a patient's cancer might respond to immunotherapy. The approach involves training a researcher to develop these agents and analyze the resulting images to better understand cancer behavior and treatment responses. This innovative method could lead to more personalized treatment options for patients with prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are prostate cancer patients, particularly those who have not responded to traditional therapies.
Not a fit: Patients with early-stage prostate cancer or those who are not candidates for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help identify which prostate cancer patients are most likely to benefit from immunotherapy, leading to more effective and tailored treatment plans.
How similar studies have performed: Similar imaging techniques have shown promise in other cancer types, suggesting that this approach could be effective, although it is still relatively novel in the context of prostate cancer.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, ALINE — JOHNS HOPKINS UNIVERSITY
- Study coordinator: THOMAS, ALINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer