Using advanced MRI to predict treatment response in brain tumors
Quantitative CEST MRI for GBM Early Response Prediction and Biopsy Guidance
This study is looking at ways to better predict how well treatments for glioblastoma, a tough brain tumor, are working by using special MRI techniques, which could help doctors create more personalized treatment plans for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10990520 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain tumor, and aims to improve early prediction of treatment responses using advanced MRI techniques. The study utilizes a method called chemical exchange saturation transfer (CEST) MRI to differentiate between true tumor progression and treatment-induced changes. By accurately assessing how patients respond to therapies like chemotherapy and anti-angiogenic treatments, the research seeks to enhance clinical decision-making and patient outcomes. This innovative approach could lead to more personalized treatment plans based on individual tumor responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are undergoing first-line therapy involving surgery, radiotherapy, and chemotherapy.
Not a fit: Patients with glioblastoma who are not receiving standard treatment or those with other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate treatment decisions for patients with glioblastoma, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for tumor response assessment, indicating that this approach could yield significant advancements in glioblastoma treatment monitoring.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Jiang, Shanshan — Johns Hopkins University
- Study coordinator: Jiang, Shanshan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.