Using advanced MRI to improve bacterial therapy for cancer
Multimodal MRI for guiding bacterial cancer therapy
This study is looking at new ways to use MRI scans to help people with tough-to-treat tumors by figuring out who might benefit from bacterial cancer therapies and tracking how well those treatments are working, all without needing any invasive procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11194247 on NIH RePORTER |
What this research studies
This research focuses on enhancing bacterial cancer therapies by developing advanced MRI techniques to guide treatment for tumors that are difficult to treat with conventional methods. The study aims to create noninvasive imaging tools that can identify which patients are likely to benefit from bacterial therapy based on tumor characteristics. By using innovative imaging technologies, researchers hope to monitor the effectiveness of the therapy in real-time, ensuring better outcomes for patients with challenging tumors. The goal is to improve the safety and efficacy of these therapies, particularly for tumors that lack sufficient blood supply.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with poorly vascularized, hypoxic tumors that have not responded well to traditional cancer treatments.
Not a fit: Patients with well-vascularized tumors or those who have not been diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer bacterial therapies for patients with hard-to-treat cancers.
How similar studies have performed: While some microbial-based therapies have reached clinical trials, the approach of using advanced MRI for guidance in this context is relatively novel and has not been extensively tested.
Where this research is happening
Baltimore, United States
- Hugo W. Moser Res Inst Kennedy Krieger — Baltimore, United States (Active)
Researchers
- Principal investigator: Liu, Guanshu — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Liu, Guanshu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.