Using advanced MRI to assess kidney function in diabetes
Hyperpolarized 13C MRI of renal mitochondrial dysfunction
['FUNDING_R21'] · WASHINGTON UNIVERSITY · NIH-10707325
This study is testing a new type of MRI that uses special imaging to look at how diabetes affects kidney function, specifically for people with diabetic nephropathy, to help doctors better understand and track changes in kidney health without needing any invasive procedures.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10707325 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new imaging technique using hyperpolarized 13C MRI to evaluate mitochondrial function in the kidneys, particularly in patients with diabetic nephropathy. By creating a specialized imaging probe that targets mitochondria, the study aims to provide a non-invasive method to monitor metabolic changes in kidney cells. This could help in understanding how diabetes affects kidney health and potentially predict disease progression. The research involves innovative chemical synthesis and advanced imaging technology to enhance the effectiveness of the probe.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic nephropathy.
Not a fit: Patients without diabetes or those who do not have any kidney-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and management of kidney health in diabetic patients, potentially reducing complications.
How similar studies have performed: While the approach of using hyperpolarized MRI is innovative, similar imaging techniques have shown promise in other areas of metabolic assessment, indicating potential for success.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VON MORZE, CORNELIUS — WASHINGTON UNIVERSITY
- Study coordinator: VON MORZE, CORNELIUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.