Using advanced MRI techniques to observe myelin repair in multiple sclerosis
Imaging remyelination in multiple sclerosis using metabolic and ultra-short echo time MRI
['FUNDING_R21'] · WASHINGTON UNIVERSITY · NIH-11038960
This study is looking at new ways to use MRI scans to see how well the brain is healing its protective covering in people with multiple sclerosis, helping us understand how treatments are working.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11038960 on ClinicalTrials.gov |
What this research studies
This research focuses on developing non-invasive imaging methods to monitor the repair of myelin sheaths in patients with multiple sclerosis (MS). By utilizing innovative techniques like hyperpolarized 13C magnetic resonance spectroscopic imaging and ultra-short echo time imaging, the study aims to track metabolic changes associated with remyelination. This could provide valuable insights into how effectively the brain is repairing itself in response to treatment. Patients may undergo MRI scans to help researchers understand the dynamics of myelin repair over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing demyelination.
Not a fit: Patients with other neurological conditions unrelated to demyelination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring of treatment responses in multiple sclerosis, potentially enhancing patient outcomes.
How similar studies have performed: While the specific combination of techniques used in this research is novel, similar imaging approaches have shown promise in other studies focused on neurological conditions.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUGLIELMETTI, CAROLINE — WASHINGTON UNIVERSITY
- Study coordinator: GUGLIELMETTI, CAROLINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.