Using advanced MRI techniques to measure blood flow and acidity in tumors
Official title: Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and Acidosis
Funded at Case Western Reserve University · NIH-10983301 · Data updated 2026-11-12
This study is working on a new way to use MRI scans to get better information about how blood flows to tumors and how acidic they are, which could help doctors make smarter treatment choices for cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $653,560 |
| NIH project number | 5R01CA269354-03 |
| Project ID | NIH-10983301 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with tumors that are being evaluated for treatment efficacy, particularly those with breast cancer.
✕Less likely to help
Patients with non-cancerous conditions or those not undergoing treatment for tumors may not receive any benefit from this research.
What this research studies
This research focuses on improving MRI technology to better assess tumor blood flow and acidity, which are important factors in cancer treatment. By developing a method called Magnetic Resonance Fingerprinting (MRF), the team aims to accurately measure how well blood is flowing to tumors and how acidic the tumor environment is. This approach involves using advanced imaging techniques in mouse cancer models to evaluate the effectiveness of different cancer therapies. Patients may benefit from more precise imaging techniques that could lead to better treatment decisions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate assessments of tumor characteristics, improving treatment strategies for cancer patients.
How similar studies have gone: Other research has shown promising results using advanced MRI techniques, indicating that this approach has the potential for success.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Flask, Christopher a — Case Western Reserve University
- Study coordinator: Flask, Christopher a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.