Using advanced mapping technology to diagnose pediatric brain tumors
Official title: Optical Genome Mapping As a Novel Diagnostic Approach in Pediatric Brain Tumors
Funded at Lurie Children's Hospital of Chicago · NIH-10859559 · Data updated 2026-11-12
This study is looking at a new way to help doctors find and treat brain tumors in kids more quickly and accurately by using a special technology that spots changes in the tumor's genes that other tests might miss, so that children can get the best care possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 23, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $699,080 |
| NIH project number | 1R01CA288496-01 |
| Project ID | NIH-10859559 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with brain tumors, particularly those whose tumors have atypical genetic features.
✕Less likely to help
Patients with brain tumors that have already been successfully diagnosed and treated using existing methods may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis and treatment of pediatric brain tumors by utilizing Optical Genome Mapping (OGM), a novel genomic technology. It aims to identify structural variants in tumors that are often missed by traditional testing methods, which can lead to delays in diagnosis and treatment. By analyzing tumor samples, the research seeks to provide more accurate and rapid identification of clinically significant genetic alterations, ultimately helping to tailor treatment plans for affected children.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnoses for pediatric brain tumors, improving treatment outcomes for young patients.
How similar studies have gone: Other research has shown promise in using advanced genomic technologies for cancer diagnosis, suggesting that this approach could yield significant advancements in pediatric oncology.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Bornhorst, Miriam a. — Lurie Children's Hospital of Chicago
- Study coordinator: Bornhorst, Miriam a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.