Using advanced imaging to identify salvageable brain tissue in hemorrhagic stroke.
MRS DITCH - Magnetic Resonance Selection with DIffusion Tensor Imaging in Cerebral Hemorrhage
This study is looking at how we can find and help areas of the brain that are damaged by bleeding but might still be saved with quick treatment, using special MRI scans to see which patients with brain hemorrhages could benefit from surgery to improve their recovery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11036304 on NIH RePORTER |
What this research studies
This research investigates the concept of a 'mechanical penumbra' in patients with intracerebral hemorrhage (ICH), which refers to areas of the brain that are under pressure and at risk of permanent damage but may still be saved if treated promptly. By utilizing diffusion tensor imaging (DTI), a specialized MRI technique, the study aims to assess the structural integrity of critical brain areas, particularly the internal capsule, which is essential for motor function. The goal is to better select patients who could benefit from interventions like hematoma evacuation, potentially improving their long-term outcomes. The research will involve analyzing imaging data to identify which patients have salvageable brain tissue surrounding the hemorrhage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an intracerebral hemorrhage and are at risk of further brain damage.
Not a fit: Patients who have already sustained irreversible brain damage or those with conditions that preclude surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with brain hemorrhages, enhancing recovery and functional outcomes.
How similar studies have performed: While the approach of using advanced imaging techniques in stroke care has shown promise in ischemic strokes, the application of this method to intracerebral hemorrhage is relatively novel and has not been extensively tested.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Koch, Sebastian — University of Miami School of Medicine
- Study coordinator: Koch, Sebastian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.