Using advanced imaging to detect lung injury in bone marrow transplant patients
Parametric Response Mapping (PRM) for the detection of chronic lung injury in hematopoietic cell transplant recipients
This study is looking at how to spot lung problems early in patients, both kids and adults, who have had a bone marrow transplant and might develop chronic graft versus host disease, using a new imaging technique that could help doctors take action sooner to improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10908593 on NIH RePORTER |
What this research studies
This research focuses on identifying chronic lung dysfunction (CLD) in patients who have undergone bone marrow transplantation, particularly those who develop chronic graft versus host disease (GVHD). By utilizing a novel imaging technique called parametric response mapping (PRM), the study aims to detect lung issues earlier than current methods allow. This could lead to timely interventions that may improve patient outcomes. The research will involve both adult and pediatric patients who are at risk for developing CLD post-transplant.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 3 years and older who have undergone bone marrow transplantation and are experiencing chronic graft versus host disease.
Not a fit: Patients who have not undergone bone marrow transplantation or do not have chronic graft versus host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and treatment of chronic lung dysfunction, significantly improving survival rates for bone marrow transplant recipients.
How similar studies have performed: Previous studies have shown that parametric response mapping is effective in identifying chronic lung dysfunction in adult bone marrow transplant patients, indicating a promising approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Yanik, Gregory a — University of Michigan at Ann Arbor
- Study coordinator: Yanik, Gregory a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.