Using advanced imaging technology to study organoids in 3D
Official title: 3D dynamic contrast optical coherence microscopy for organoid studies
Funded at University of Colorado · NIH-10936450 · Data updated 2026-11-12
This study is testing a new way to take detailed 3D pictures of tiny clusters of living cells called organoids, which could help us better understand how cells behave and interact, ultimately leading to better treatments for various diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $402,135 |
| NIH project number | 1R01EB036005-01 |
| Project ID | NIH-10936450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect cellular structures or organoid development, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular dynamics may not receive direct benefits from this research.
What this research studies
This research focuses on developing a new imaging technique called dynamic contrast optical coherence microscopy (DyC-OCM) to visualize organoids in three dimensions. By capturing high-resolution images of living cells, the study aims to provide insights into cellular behaviors and interactions within these organoid structures. Patients may benefit from this research as it could lead to improved understanding and treatment of various diseases by enhancing the way we observe cellular dynamics in real-time. The approach combines advanced imaging technology with innovative methodologies to explore cellular viability and growth patterns.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases at the cellular level, potentially improving treatment strategies.
How similar studies have gone: Previous research using similar imaging techniques has shown promise in enhancing our understanding of cellular processes, indicating a potential for success in this novel application.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Huang, Shu-Wei — University of Colorado
- Study coordinator: Huang, Shu-Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.