Using advanced imaging techniques to study Alzheimer's disease brain tissue.
Official title: Photocleavable Mass-Tags for Spatial Multiomics of Alzheimer’s Brain Tissue
Funded at Ambergen, INC · NIH-10684250 · Data updated 2026-11-12
This study is exploring new ways to take detailed pictures of brain tissue affected by Alzheimer's disease to better understand how the disease works, which could lead to better ways to diagnose and treat patients in the future.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ambergen, INC NIH-funded |
| Lab location | 1 site (Watertown, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,081,032 |
| NIH project number | 5R44AG078097-02 |
| Project ID | NIH-10684250 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on developing innovative imaging methods to analyze brain tissue affected by Alzheimer's disease. By utilizing photocleavable mass-tags, the project aims to create a detailed map of various molecular components involved in Alzheimer's pathology. This approach will allow researchers to visualize the spatial distribution of key molecules at a cellular level, which is crucial for understanding the disease's progression and identifying potential therapeutic targets. Patients may benefit from improved diagnostics and treatment strategies that arise from this enhanced understanding of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for Alzheimer's disease.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques for studying neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ambergen, INC
Watertown, United States Active
Researchers
- Principal investigator: Lim, Mark — Ambergen, INC
- Study coordinator: Lim, Mark
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.