Using advanced genome data to better understand complex human traits
Official title: Integrating the reference pangenome with biobank-scale data for complex trait analysis
Funded at University of California, San Diego · NIH-10977573 · Data updated 2026-11-12
This study is looking at a new way to understand our genes by using a special type of genetic map, which could help researchers find important differences in DNA that affect health, so that patients can get better, more personalized treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,310,799 |
| NIH project number | 1U01HG013755-01 |
| Project ID | NIH-10977573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with complex traits or conditions that may have a genetic component.
✕Less likely to help
Patients with conditions that are purely environmental or non-genetic in nature may not benefit from this research.
What this research studies
This research aims to integrate a new type of genome reference, known as the pangenome, with large-scale biobank data to enhance our understanding of complex human traits. By analyzing diverse genetic sequences, the project seeks to identify and visualize genetic variations that may contribute to various health conditions. The approach involves developing user-friendly tools that allow researchers to explore these complex genomic regions more effectively, ultimately improving the detection of medically relevant genetic variants. Patients may benefit from improved genetic insights that could lead to better-targeted treatments and personalized medicine.
Why it matters
Potential benefit: If successful, this research could lead to more accurate identification of genetic factors influencing health, enabling personalized treatment strategies for patients.
How similar studies have gone: Previous research has shown promise in using pangenomes for genetic analysis, indicating that this approach could yield significant advancements in understanding complex traits.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Gymrek, Melissa — University of California, San Diego
- Study coordinator: Gymrek, Melissa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.