Using advanced fluorescent labels to classify cells in intact tissue samples
Hyperplexed Quantum Dots for Multidimensional Cell Classification in Intact Tissue
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · NIH-10811577
This study is exploring a new way to use special glowing particles to help scientists see and identify different types of cells in fat tissue, which could improve our understanding of obesity and diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN (nih funded) |
| Locations | 1 site (CHAMPAIGN, UNITED STATES) |
| Trial ID | NIH-10811577 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new fluorescent labels using semiconductor quantum dots to classify individual cells within intact three-dimensional tissues. By employing hyperspectral light sheet microscopy, the researchers aim to analyze over 30 distinct molecules in a single staining step, which will enhance the ability to identify and map various cell types in tissues like adipose (fat) tissue. This innovative approach addresses current limitations in optical microscopy, allowing for more precise cell classification and understanding of cellular environments, particularly in conditions related to obesity and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity or diabetes, particularly those whose conditions may be linked to adipose tissue characteristics.
Not a fit: Patients without obesity or diabetes, or those who do not have any related metabolic conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for conditions like obesity and diabetes by providing a better understanding of cell types and their interactions in adipose tissue.
How similar studies have performed: Other research has shown promising results using similar advanced imaging techniques, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
CHAMPAIGN, UNITED STATES
- UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN — CHAMPAIGN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, ANDREW MICHAEL — UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- Study coordinator: SMITH, ANDREW MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.