Using advanced data analysis to understand Alzheimer's disease and related dementias
Official title: Robust Mendelian Randomization Framework with Multi-Omics Data for Alzheimer's Disease and Related Dementias
Funded at Columbia University Health Sciences · NIH-11097236 · Data updated 2026-11-12
This study is looking at how different types of biological data can help find early signs of Alzheimer's and related dementias, so we can improve diagnosis and create better treatments for people who are just starting to experience symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $477,904 |
| NIH project number | 5R01AG086379-02 |
| Project ID | NIH-11097236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease or those in the early stages of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates how multi-omics data can help identify biomarkers related to Alzheimer's disease and related dementias. By employing a method called Mendelian randomization, the study aims to eliminate biases that can affect the accuracy of findings. The goal is to enhance early diagnosis and develop targeted interventions for patients in the preclinical and early stages of the disease. This approach focuses on understanding the complex biological processes involved in neurodegeneration.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, allowing for timely and personalized treatment options.
How similar studies have gone: Previous research using similar multi-omics approaches has shown promise in identifying biomarkers for various diseases, suggesting potential for success in this novel application.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Liu, Zhonghua — Columbia University Health Sciences
- Study coordinator: Liu, Zhonghua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.