Using advanced cryo-electron microscopy to analyze biological structures
Glacios 2 Cryo-TEM for Structure Analysis
This study is all about getting a super advanced microscope to help scientists at Mount Sinai better understand how diseases work by looking closely at tiny biological samples, making their research faster and more accurate.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10850289 on NIH RePORTER |
What this research studies
This research focuses on acquiring a state-of-the-art Glacios 2 cryo-transmission electron microscope (cryo-TEM) to enhance the capabilities of structural biology at the Icahn School of Medicine at Mount Sinai. The microscope will allow researchers to collect high-resolution cryo-EM data on various biological samples, facilitating a better understanding of disease mechanisms. By enabling local data collection, the project aims to streamline the research process and improve the quality of structural analysis. The initiative also includes the establishment of necessary infrastructure and support for ongoing cryo-EM operations.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with diseases that are being studied through structural biology techniques, particularly those related to the biological systems analyzed using cryo-EM.
Not a fit: Patients with conditions unrelated to the biological systems being investigated through cryo-EM may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could significantly advance our understanding of various diseases by providing detailed structural insights into biological systems.
How similar studies have performed: Other research utilizing cryo-electron microscopy has shown significant success in advancing structural biology, indicating that this approach is both established and promising.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Aggarwal, Aneel K. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Aggarwal, Aneel K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.