Using advanced cryo-electron microscopy to analyze biological structures
Official title: Glacios 2 Cryo-TEM for Structure Analysis
Funded at Icahn School of Medicine at Mount Sinai · NIH-10850289 · Data updated 2026-11-12
This study is all about getting a super advanced microscope to help scientists at Mount Sinai better understand how diseases work by looking closely at tiny biological samples, making their research faster and more accurate.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2024 |
| Project end | August 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $2,000,000 |
| NIH project number | 1S10OD036213-01 |
| Project ID | NIH-10850289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with diseases that are being studied through structural biology techniques, particularly those related to the biological systems analyzed using cryo-EM.
✕Less likely to help
Patients with conditions unrelated to the biological systems being investigated through cryo-EM may not receive direct benefits from this research.
What this research studies
This research focuses on acquiring a state-of-the-art Glacios 2 cryo-transmission electron microscope (cryo-TEM) to enhance the capabilities of structural biology at the Icahn School of Medicine at Mount Sinai. The microscope will allow researchers to collect high-resolution cryo-EM data on various biological samples, facilitating a better understanding of disease mechanisms. By enabling local data collection, the project aims to streamline the research process and improve the quality of structural analysis. The initiative also includes the establishment of necessary infrastructure and support for ongoing cryo-EM operations.
Why it matters
Potential benefit: If successful, this research could significantly advance our understanding of various diseases by providing detailed structural insights into biological systems.
How similar studies have gone: Other research utilizing cryo-electron microscopy has shown significant success in advancing structural biology, indicating that this approach is both established and promising.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Aggarwal, Aneel K. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Aggarwal, Aneel K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.