Using adenosine to reduce pain from bone fractures
Modulation of local adenosine signaling to attenuate fracture pain
This study is looking at how a natural substance called adenosine can help relieve pain from broken bones by using a special injection that delivers it right where it's needed, making recovery easier and reducing the need for stronger pain medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11061266 on NIH RePORTER |
What this research studies
This research investigates the use of adenosine, a naturally occurring molecule, to manage pain associated with orthopedic fractures. The approach involves developing a special injectable biomaterial that delivers adenosine directly to the fracture site, potentially enhancing pain relief while promoting healing. By understanding how adenosine works in the body, the researchers aim to create effective treatment strategies that minimize the need for traditional pain medications, which can have harmful side effects. Patients may be monitored for pain levels and healing progress throughout the treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from orthopedic fractures who are seeking effective pain management solutions.
Not a fit: Patients with chronic pain conditions unrelated to fractures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective way to manage pain from fractures, improving recovery outcomes for patients.
How similar studies have performed: Previous research has shown promising results using adenosine for pain management and bone healing, indicating that this approach may be effective.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Varghese, Shyni — Duke University
- Study coordinator: Varghese, Shyni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.