Using a virus to improve breast cancer treatment with immune therapies

Who could benefit from this research

What this research studies

This research investigates a novel approach to enhance the effectiveness of existing immune therapies for triple negative breast cancer (TNBC) by using an oncolytic adenovirus that targets TGFβ, a protein that suppresses the immune response. The study aims to deliver this virus systemically to patients, which could help overcome resistance to current treatments like anti-PD-1 and anti-CTLA-4 therapies. By inhibiting TGFβ pathways, the goal is to create a more favorable tumor environment for immune attack. Patients may receive this treatment in conjunction with standard therapies to improve their outcomes.

Why it matters

Where this research is happening

• Endeavor Health Clinical Operations
  Evanston, United States Active

Researchers

• Principal investigator: Xu, Weidong — Endeavor Health Clinical Operations
• Study coordinator: Xu, Weidong

Related research

Other NIH-funded projects on the same topics.

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• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11608792

• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

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  NIH research University of Louisville · Louisville, United States · NIH-11567535

• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

  Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

  A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.

  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.