Using a viral gene drive to treat herpes simplex virus infections
Viral gene drive as a novel curative therapy for HSV infection
This study is testing a new way to treat herpes infections using a special tool called CRISPR to help replace the virus with a safer version, aiming to lower symptoms and prevent future outbreaks for people living with chronic herpes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11041074 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treating herpes simplex virus (HSV) infections by utilizing a CRISPR-based viral gene drive. The method aims to replace wild-type HSV with an engineered version that can reduce viral levels and prevent outbreaks. By targeting the latent reservoirs of the virus in neurons, the therapy seeks to provide a long-term solution for patients suffering from chronic HSV disease. The research will explore the effectiveness of this gene drive in spreading through the viral population to achieve a curative effect.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from recurrent herpes simplex virus infections.
Not a fit: Patients who do not have herpes simplex virus infections will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a groundbreaking curative therapy for patients with chronic HSV infections.
How similar studies have performed: While the concept of using gene drives in viruses is innovative, similar approaches in other contexts have shown promise, indicating potential for success.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Walter, Marius — Fred Hutchinson Cancer Center
- Study coordinator: Walter, Marius
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.