Using a therapy to improve kidney transplant outcomes from deceased donors
Official title: Intra-graft C1 esterase inhibitor therapy for deceased kidney transplantation
Funded at Cedars-Sinai Medical Center · NIH-10928522 · Data updated 2026-11-12
This study is looking at whether giving a special treatment to kidney donors before their organs are transplanted can help improve the success of kidney transplants, especially for those receiving kidneys from deceased donors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2031 |
| Funding year | 2024 |
| Award (this year) | $2,216,525 |
| NIH project number | 1R01AI184203-01 |
| Project ID | NIH-10928522 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who are receiving a kidney transplant from a deceased donor.
✕Less likely to help
Patients who are receiving kidney transplants from living donors or those who are not eligible for transplantation may not benefit from this research.
What this research studies
This research investigates the use of C1 esterase inhibitor therapy to enhance kidney transplant outcomes, particularly for organs from deceased donors. It focuses on reducing ischemia-reperfusion injury, a common complication that negatively affects transplant success. The approach involves administering the therapy directly into the donor organ's renal artery before transplantation. By doing so, the study aims to improve kidney function and overall transplant success rates for recipients.
Why it matters
Potential benefit: If successful, this research could lead to significantly improved kidney transplant outcomes for patients receiving organs from deceased donors.
How similar studies have gone: Previous pilot trials have shown promising results with similar approaches, indicating potential for success in this larger study.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Heeger, Peter Scott — Cedars-Sinai Medical Center
- Study coordinator: Heeger, Peter Scott
Related research
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-
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Biomarker-guided Immunosuppression in Kidney Transplant Patients
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Helping the immune system accept a donated kidney in patients without prior sensitization
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This project works to reduce harmful donor-specific antibodies in people who are sensitized and need a kidney transplant so their new organ lasts longer.
-
Reducing geographic disparities in kidney transplant access with AI and operations research
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-
Centralized patient coaching to boost live donor kidney transplantation
A US-wide program trains patients, caregivers, and their networks with coaching to help them pursue living donor kidney transplantation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.