Using a therapy to improve kidney transplant outcomes from deceased donors
Intra-graft C1 esterase inhibitor therapy for deceased kidney transplantation
This study is looking at whether giving a special treatment to kidney donors before their organs are transplanted can help improve the success of kidney transplants, especially for those receiving kidneys from deceased donors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10928522 on NIH RePORTER |
What this research studies
This research investigates the use of C1 esterase inhibitor therapy to enhance kidney transplant outcomes, particularly for organs from deceased donors. It focuses on reducing ischemia-reperfusion injury, a common complication that negatively affects transplant success. The approach involves administering the therapy directly into the donor organ's renal artery before transplantation. By doing so, the study aims to improve kidney function and overall transplant success rates for recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are receiving a kidney transplant from a deceased donor.
Not a fit: Patients who are receiving kidney transplants from living donors or those who are not eligible for transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significantly improved kidney transplant outcomes for patients receiving organs from deceased donors.
How similar studies have performed: Previous pilot trials have shown promising results with similar approaches, indicating potential for success in this larger study.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Heeger, Peter Scott — Cedars-Sinai Medical Center
- Study coordinator: Heeger, Peter Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.