Using a targeted approach to improve memory deficits in Alzheimer's disease
Official title: Redirected CaMKII for restoring deficits in Alzheimer's disease models
Funded at Wayne State University · NIH-11170685 · Data updated 2026-11-12
This study is looking at how changing the way a certain protein works in the brain might help improve memory and thinking skills for people with Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $182,915 |
| NIH project number | 5R21AG083760-02 |
| Project ID | NIH-11170685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how redirecting a specific protein, CaMKIIa, can help restore memory and cognitive functions in models of Alzheimer's disease. The study focuses on understanding the changes in this protein's distribution in the brain and its relationship with tau pathology, which is a key feature of Alzheimer's. By using innovative techniques to deliver this intervention, the research aims to address the underlying cellular issues that contribute to memory loss in Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve memory and cognitive function in individuals with Alzheimer's disease.
How similar studies have gone: While the approach of targeting CaMKIIa in Alzheimer's models is promising, it is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Park, Joongkyu — Wayne State University
- Study coordinator: Park, Joongkyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.