Using a special treatment to improve stroke recovery
tPA nanoconjugate for stroke therapy
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10676791
This study is exploring a new treatment for stroke that combines a common medication with special tiny particles to help protect the brain and improve recovery, and it's designed for people who have recently had a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10676791 on ClinicalTrials.gov |
What this research studies
This research investigates a new approach to stroke therapy by combining the FDA-approved drug tPA with antioxidant enzymes delivered in nanoparticles. The goal is to enhance the effectiveness of tPA while minimizing its side effects, such as bleeding and damage to the blood-brain barrier. By administering this treatment shortly after a stroke, the researchers aim to reduce brain injury and promote healing. Patients who have suffered a stroke may benefit from this innovative therapy that seeks to improve recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have experienced an acute ischemic stroke and are within the treatment window for tPA.
Not a fit: Patients who have had a hemorrhagic stroke or are outside the treatment window for tPA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective treatment for stroke that reduces brain damage and improves recovery.
How similar studies have performed: Previous studies have shown promising results with similar approaches, indicating potential for success in this novel treatment strategy.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LABHASETWAR, VINOD D — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: LABHASETWAR, VINOD D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.