Using a special dye to help remove breast tumors more effectively
Fluorescence-guided resection of breast tumors using a topically-applied molecular probe
This study is testing a new way to help surgeons find and remove all cancer cells during breast cancer surgery using a special light-up probe, which could lead to better outcomes and fewer follow-up treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10745913 on NIH RePORTER |
What this research studies
This research investigates a new method for improving breast cancer surgery by using a topically-applied molecular probe that fluoresces when it binds to cancer cells. The goal is to enhance the surgeon's ability to identify and remove all cancerous tissue during breast-conserving surgery, which is crucial for reducing the risk of cancer recurrence. By providing real-time feedback during surgery, this approach aims to minimize the chances of positive margins, which can lead to further treatments and poorer outcomes. Patients may benefit from a more successful surgery with potentially fewer follow-up procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with breast cancer who are eligible for breast-conserving surgery.
Not a fit: Patients with advanced breast cancer requiring mastectomy or those not eligible for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective breast cancer surgeries, reducing the need for additional treatments and improving patient outcomes.
How similar studies have performed: Other research has shown promising results with fluorescence-guided surgery techniques in various cancers, indicating potential for success in this novel application for breast cancer.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Basilion, James Peter — Case Western Reserve University
- Study coordinator: Basilion, James Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.