Using a special cardiac muscle patch to repair heart damage
Myocardial Repair with a Novel Engineered Cardiac Muscle Patch
This study is exploring a new way to help heal damaged hearts by creating a special patch made from stem cells, which could help more of these cells survive and work better in the heart, potentially benefiting patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10471216 on NIH RePORTER |
What this research studies
This research focuses on improving heart repair through cellular transplantation by developing a novel cardiac muscle patch made from human induced pluripotent stem cells (hiPSCs). The approach aims to enhance the engraftment rate of donor cells, which is crucial for effective heart repair. By genetically modifying these stem cells to increase their proliferation, the researchers hope to improve the survival and integration of these cells in damaged heart tissue. Patients may benefit from this innovative technique if it proves successful in clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart damage or conditions such as myocardial infarction who may benefit from advanced cellular therapies.
Not a fit: Patients with non-cardiac conditions or those who do not have significant heart damage may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for heart damage, potentially improving recovery and quality of life for patients with heart conditions.
How similar studies have performed: Previous research has shown promise in using engineered cardiac patches for heart repair, indicating that this approach may build on existing successful strategies.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Zhu, Wuqiang — Mayo Clinic Arizona
- Study coordinator: Zhu, Wuqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.