Using a special capsule to deliver cell therapy to restore ovarian function in animals
Immuno-Isolating capsule for delivery of cell-based therapy for restoration of ovarian endocrine function in an animal model
This study is exploring a new way to help young women who have premature ovarian insufficiency, often due to cancer treatments, by using a special capsule to deliver ovarian tissue in monkeys, with hopes of restoring their ovarian function and helping them start puberty again.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11120899 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treat premature ovarian insufficiency (POI), a condition often caused by cancer treatments like chemotherapy. The study focuses on using an immuno-isolating capsule to deliver ovarian allografts in non-human primates, aiming to restore normal ovarian function and initiate puberty. By testing this method in a more clinically relevant animal model, the researchers hope to overcome limitations seen in previous rodent studies. The ultimate goal is to develop a therapy that could benefit young female cancer survivors facing fertility and hormonal challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are young female cancer survivors who have experienced premature ovarian insufficiency due to cancer treatments.
Not a fit: Patients who are not female or those who have not undergone cancer treatments that lead to ovarian insufficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore ovarian function and fertility in young female cancer survivors.
How similar studies have performed: While similar approaches have shown promise in rodent models, this research aims to extend those findings to non-human primates, marking a significant step towards clinical application.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shikanov, Ariella — University of Michigan at Ann Arbor
- Study coordinator: Shikanov, Ariella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.