Using a probiotic to protect the gut from radiation damage
Official title: Investigation of the mechanisms of H-ARS mitigation by the orally administrated GI-ARS mitigator LR-IFN-beta
Funded at Chromologic, LLC · NIH-11017408 · Data updated 2026-11-12
This study is testing a special probiotic that has been modified to help heal your gut after radiation exposure, like what might happen in a nuclear emergency, and it’s designed to be taken easily by mouth.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chromologic, LLC NIH-funded |
| Lab location | 1 site (Monrovia, United States) |
| Project start | December 17, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $470,309 |
| NIH project number | 1U01AI187044-01 |
| Project ID | NIH-11017408 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk of radiation exposure, such as those in emergency response roles or patients undergoing abdominal radiotherapy.
✕Less likely to help
Patients who have not been exposed to radiation or those with conditions unrelated to gastrointestinal health may not benefit from this research.
What this research studies
This research investigates a genetically modified probiotic designed to deliver a therapeutic agent directly to the gastrointestinal tract. The goal is to reduce damage and promote tissue regeneration after exposure to ionizing radiation, which can occur during nuclear incidents. By targeting intestinal stem cells, this approach aims to improve survival rates from acute radiation syndrome, particularly gastrointestinal acute radiation syndrome. The probiotic can be taken orally, making it suitable for emergency situations.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and recovery for individuals exposed to harmful radiation.
How similar studies have gone: While this approach is innovative, similar strategies using probiotics for therapeutic delivery have shown promise in other contexts, but this specific application is novel.
Where this research is happening
-
Chromologic, LLC
Monrovia, United States Active
Researchers
- Principal investigator: Rogers, Claude J. — Chromologic, LLC
- Study coordinator: Rogers, Claude J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.