Using a perfused organ panel to test chemical toxicity without live animals
Perfused organ panel as an animal surrogate for chemical toxicity testing
['FUNDING_SBIR_2'] · LENA BIOSCIENCES, INC. · NIH-10837692
This study is working on a new way to test how harmful chemicals are by using a special setup that acts like real organs, so we can learn about their effects without using live animals, making it safer and more humane.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LENA BIOSCIENCES, INC. (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10837692 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method for testing the toxicity of chemicals using a perfused organ panel, which mimics the function of real organs without the need for live animals. The approach involves creating organ cultures that can respond to toxic substances, allowing researchers to observe how these substances affect biological systems. By utilizing cells from commonly used animal species, the study aims to replicate the biological interactions and toxic responses seen in traditional animal testing. This innovative method seeks to provide reliable data that can replace or reduce animal testing in toxicity assessments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals concerned about the safety of chemicals and environmental toxins, particularly those with conditions affected by toxic exposures.
Not a fit: Patients who are not affected by environmental toxins or who do not have conditions related to chemical exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer chemical testing methods that minimize the use of animals and provide more accurate results for human health.
How similar studies have performed: Other research has shown promise in using organ-on-a-chip technologies for toxicity testing, indicating that this approach could be a significant advancement in the field.
Where this research is happening
ATLANTA, UNITED STATES
- LENA BIOSCIENCES, INC. — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VUKASINOVIC, JELENA — LENA BIOSCIENCES, INC.
- Study coordinator: VUKASINOVIC, JELENA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.