Using a parasite protein to reduce inflammation
Targeting professional APCs using Fasciola hepatica FABP to suppresses inflammation
This study is exploring how a protein from a liver parasite might help reduce inflammation in the body, with the hope of finding new treatments for people dealing with inflammatory diseases like colitis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-10670212 on NIH RePORTER |
What this research studies
This research investigates how a protein from the Fasciola hepatica parasite can help control inflammation in the body. By understanding how this protein interacts with the immune system, researchers aim to develop new treatments that can effectively manage inflammatory diseases. The approach involves studying the immune responses triggered by the parasite and its proteins, particularly focusing on their ability to suppress harmful inflammation while maintaining immune function. Patients may benefit from insights that could lead to innovative therapies for conditions like colitis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory conditions such as ulcerative colitis.
Not a fit: Patients with non-inflammatory conditions or those who do not respond to immune modulation therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce inflammation in patients with autoimmune diseases.
How similar studies have performed: Previous studies have shown promise in using helminth therapy for managing inflammation, suggesting that this approach could be a viable treatment option.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Espino, Ana M — University of Puerto Rico Med Sciences
- Study coordinator: Espino, Ana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.