Using a new pacing method to help heart failure patients who don't respond to standard treatments
Official title: Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-response in Patients With Heart Failure: A Randomized Controlled Trial
Funded at Minneapolis VA Medical Center · NIH-10862628 · Data updated 2026-11-12
This study is looking at a new way to help heart failure patients who haven't felt better with regular treatments by using a special pacing technique, and it will track their heart health over time to see if this approach makes a difference.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Minneapolis VA Medical Center NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 5IK2CX002525-02 |
| Project ID | NIH-10862628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are heart failure patients, particularly those with reduced ejection fraction and left bundle branch block, who have not seen improvement from conventional CRT.
✕Less likely to help
Patients without heart failure or those who have not been diagnosed with left bundle branch block may not benefit from this research.
What this research studies
This research investigates a novel approach to cardiac resynchronization therapy (CRT) for heart failure patients who have not improved with traditional treatments. The study will explore the use of left bundle branch area pacing as a potential rescue strategy to enhance cardiac function. Patients will undergo cardiac MRI assessments to monitor their heart function over time, providing valuable insights into the effectiveness of this innovative therapy. The research aims to improve care for those suffering from heart failure, particularly focusing on those with reduced ejection fraction.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for heart failure patients who currently do not respond to standard therapies.
How similar studies have gone: While the approach of using left bundle branch area pacing is innovative, similar studies have shown promise in improving outcomes for patients with heart failure, indicating potential for success.
Where this research is happening
-
Minneapolis VA Medical Center
Minneapolis, United States Active
Researchers
- Principal investigator: Carlson, Selma D — Minneapolis VA Medical Center
- Study coordinator: Carlson, Selma D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.