Using a new oral medication to treat endometriosis and its pain
Official title: Phase II- Repurposing CRH antagonists for the treatment of endometriosis
Funded at Sur180 Therapeutics, LLC · NIH-11183203 · Data updated 2026-11-12
This study is testing a new pill to help women with endometriosis manage their pain and reduce the need for surgeries, making life a little easier for those dealing with this challenging condition.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sur180 Therapeutics, LLC NIH-funded |
| Lab location | 1 site (Mcallen, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,239,987 |
| NIH project number | 2R44HD109055-02A1 |
| Project ID | NIH-11183203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of childbearing age who are diagnosed with endometriosis and experience chronic pain associated with the condition.
✕Less likely to help
Patients who do not have endometriosis or those who are not experiencing significant pain related to the condition may not benefit from this research.
What this research studies
This research focuses on developing an oral medication aimed at managing endometriosis and alleviating associated pain. The approach seeks to reduce the need for repeated surgeries, which are common for women suffering from this condition. Endometriosis affects a significant number of women and often leads to chronic pain and infertility. The research builds on promising results from earlier studies that showed the drug candidate could effectively reduce pain and disease markers without disrupting hormonal cycles.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that alleviates pain and slows the progression of endometriosis, potentially improving quality of life for many women.
How similar studies have gone: Previous studies have shown success with similar approaches in managing endometriosis pain, indicating potential for this new treatment to be effective.
Where this research is happening
-
Sur180 Therapeutics, LLC
Mcallen, United States Active
Researchers
- Principal investigator: Torres-Reveron, Annelyn — Sur180 Therapeutics, LLC
- Study coordinator: Torres-Reveron, Annelyn
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.