Using a new heart pump to help children with severe heart failure
Official title: 2/2 Circulatory Support in Pediatric Heart Failure Patients Using the Jarvik 2015 LVAD: A Pivotal Trial
Funded at New England Research Institutes, INC. · NIH-10591083 · Data updated 2026-11-12
This study is looking at how well the Jarvik 2015 heart pump can help kids with severe heart failure who haven't improved with regular treatments, giving them a better chance while they wait for a heart transplant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New England Research Institutes, INC. NIH-funded |
| Lab location | 1 site (Wilmington, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $1,061,181 |
| NIH project number | 1U24HL163316-01A1 |
| Project ID | NIH-10591083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized children with severe heart failure who have not responded to medical therapy and are awaiting heart transplantation.
✕Less likely to help
Patients with heart failure who are not hospitalized or those who do not meet the criteria for heart transplantation may not benefit from this research.
What this research studies
This research investigates the use of the Jarvik 2015 left ventricular assist device (LVAD) as a temporary solution for children suffering from severe heart failure who do not respond to standard treatments. The study will involve multiple centers and aims to gather important safety and effectiveness data to support the device's approval for use in pediatric patients. By providing a bridge to heart transplantation, this device could potentially improve the quality of life for these young patients while they await a suitable donor heart.
Why it matters
Potential benefit: If successful, this research could provide a new, safe, and effective option for managing severe heart failure in children, potentially improving their chances of survival and quality of life.
How similar studies have gone: While the use of left ventricular assist devices in adults has shown success, this specific application in pediatric patients is novel and aims to address significant gaps in current treatment options.
Where this research is happening
-
New England Research Institutes, INC.
Wilmington, United States Active
Researchers
- Principal investigator: Magnavita, Ashley — New England Research Institutes, INC.
- Study coordinator: Magnavita, Ashley
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.