Using a nasal spray to help brain recovery after oxygen deprivation at birth
Intranasal LIF to improve neurological recovery from perinatal hypoxia-ischema
This study is looking at how a special protein given through the nose might help newborns who didn't get enough oxygen at birth recover better by encouraging their brain cells to heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10824210 on NIH RePORTER |
What this research studies
This research investigates how a protein called leukemia inhibitor factor (LIF) can be administered through the nose to promote brain recovery in newborns who have experienced a lack of oxygen during birth. The study focuses on understanding the role of LIF in stimulating neural stem cells to repair brain damage and improve neurological function. By using mouse models that simulate this condition, researchers aim to determine the effectiveness of LIF in reducing brain cell loss and enhancing recovery. The approach is non-invasive, making it a potentially safer option for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns who have experienced oxygen deprivation during birth, particularly those at risk for neurological deficits.
Not a fit: Patients who have not experienced perinatal hypoxia-ischemia or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve neurological outcomes for infants affected by perinatal hypoxia-ischemia.
How similar studies have performed: Previous studies have shown promise in using similar cytokine therapies for neurological recovery, suggesting a potential for success in this approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Levison, Steven W — Rutgers Biomedical and Health Sciences
- Study coordinator: Levison, Steven W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.