Using a modified kidney protein to treat kidney injury
Validation of recombinant truncated Tamm-Horsfall protein as a therapeutic tool for kidney injury
This study is looking at a special version of a protein that might help people with acute kidney injury by reducing inflammation and helping their kidneys heal, especially for those who don’t have enough of this protein naturally.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rlr VA Medical Center NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10927459 on NIH RePORTER |
What this research studies
This research investigates the use of a modified version of Tamm-Horsfall protein (THP) as a potential treatment for acute kidney injury (AKI). The study aims to understand how this protein can help reduce inflammation and promote healing in the kidneys, especially in patients who have a deficiency of THP. By administering this recombinant protein, the researchers hope to improve kidney function and recovery in affected individuals. The approach includes assessing the safety and effectiveness of the treatment through pharmacokinetic studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with acute kidney injury, particularly those with a history of chronic kidney disease or THP deficiency.
Not a fit: Patients with stable kidney function and no history of acute kidney injury are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients suffering from acute kidney injury.
How similar studies have performed: Previous research has shown promising results with similar therapeutic approaches targeting kidney injury, suggesting potential for success in this study.
Where this research is happening
Indianapolis, United States
- Rlr VA Medical Center — Indianapolis, United States (Active)
Researchers
- Principal investigator: Ashkar, Tarek Maurice — Rlr VA Medical Center
- Study coordinator: Ashkar, Tarek Maurice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.