Using a histamine test to improve asthma treatment in children
Official title: A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma
Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-10846557 · Data updated 2026-11-12
This study is looking for a simple way to help doctors figure out which kids with asthma will benefit from antihistamines, so they can get the best treatment without unnecessary side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | June 5, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $283,465 |
| NIH project number | 5R01HD100545-05 |
| Project ID | NIH-10846557 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have persistent asthma and require daily controller medication.
✕Less likely to help
Patients with asthma who do not require daily medication or those with non-allergic asthma may not benefit from this research.
What this research studies
This research aims to identify a reliable biomarker that can predict how well children with asthma will respond to antihistamine treatments. By using a method called Histamine Iontophoresis with Laser Doppler monitoring (HILD), the study seeks to provide a non-invasive way to guide treatment decisions for pediatric patients suffering from allergic asthma. The goal is to enhance the effectiveness of asthma therapies while minimizing side effects from medications that may not work for every child. This approach addresses the variability in treatment responses seen in many children with persistent asthma.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective asthma treatments for children, improving their overall health and quality of life.
How similar studies have gone: Previous research has shown promise in using biomarkers to guide asthma treatment, but this specific approach using HILD is novel and has not been extensively tested.
Where this research is happening
-
Children's Mercy Hosp (Kansas City, Mo)
Kansas City, United States Active
Researchers
- Principal investigator: Jones, Bridgette L. — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Jones, Bridgette L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.