Using a drug for Gaucher Disease to enhance cancer treatment in triple-negative breast cancer.

Who could benefit from this research

What this research studies

This research investigates the potential of repurposing eliglustat, a drug approved for Gaucher Disease, to treat triple-negative breast cancer (TNBC). The approach focuses on targeting a specific lipid metabolism feature in TNBC cells, which may lead to increased cancer cell death and stimulate an immune response against the tumor. By promoting the accumulation of certain toxic lipids, the research aims to shift cancer cell behavior from survival to death, while also enhancing the infiltration of immune cells into the tumor. The study will evaluate the effectiveness of eliglustat in preclinical models to establish its role as a new treatment option for TNBC patients.

Why it matters

Where this research is happening

• University of Tx Md Anderson Can Ctr
  Houston, United States Active

Researchers

• Principal investigator: Fahrmann, Johannes F — University of Tx Md Anderson Can Ctr
• Study coordinator: Fahrmann, Johannes F

Related research

Other NIH-funded projects on the same topics.

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• A new peptide therapy to help treat metastatic triple-negative breast cancer

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.