Using a device to help people breathe during opioid overdoses
Transcutaneous Phrenic Nerve Stimulation for Treating Opioid Overdose
This study is testing a new device that helps people breathe better during an opioid overdose, making it easier for anyone to assist someone in need until help arrives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coridea, LLC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10681111 on NIH RePORTER |
What this research studies
This research aims to develop a device called the Automated External Respiration System (AERS) that can help individuals who are experiencing respiratory depression due to opioid overdose. The device works by stimulating the phrenic nerve to maintain adequate breathing until medical help can arrive or the effects of the opioids wear off. The research will involve testing the device's safety and effectiveness in human volunteers after initial successful trials in animal models. The goal is to create a community-friendly device that can be used by anyone, similar to how Automated External Defibrillators (AEDs) are used today.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of opioid overdose or those who have experienced respiratory depression due to opioid use.
Not a fit: Patients who do not use opioids or have no risk of respiratory depression from drug use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a life-saving tool for individuals experiencing opioid overdoses, potentially reducing the number of deaths from respiratory failure.
How similar studies have performed: Previous research has shown success with similar approaches in animal models, but this specific device is novel and has not yet been tested in humans.
Where this research is happening
New York, United States
- Coridea, LLC — New York, United States (Active)
Researchers
- Principal investigator: Levin, Howard — Coridea, LLC
- Study coordinator: Levin, Howard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.