Using a CRISPR approach to reduce lung inflammation in people with HIV and COPD
Official title: A CRISP(e)R approach to alleviating HIV-associated COPD
Funded at Florida International University · NIH-11173860 · Data updated 2026-11-12
This study is looking at how HIV can cause lung problems like COPD and aims to find ways to reduce lung inflammation and improve breathing for people living with HIV by using advanced techniques to target specific molecules in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $459,376 |
| NIH project number | 5R01HL176254-02 |
| Project ID | NIH-11173860 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing symptoms of COPD or other lung-related issues.
✕Less likely to help
Patients who do not have HIV or those without any lung-related conditions may not benefit from this research.
What this research studies
This research investigates the connection between HIV and chronic obstructive pulmonary disease (COPD), focusing on how HIV-related lung inflammation contributes to the development of COPD. The study aims to identify the underlying mechanisms that lead to lung damage in individuals living with HIV, particularly the role of specific microRNAs and signaling pathways. By utilizing CRISPR technology, the researchers hope to modify these pathways to alleviate inflammation and improve lung health in affected patients. This approach could lead to new therapeutic strategies for managing lung diseases in people with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung inflammation and COPD in individuals living with HIV, potentially enhancing their quality of life and longevity.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in lung diseases, suggesting that this approach could be effective.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Chinnapaiyan, Srinivasan — Florida International University
- Study coordinator: Chinnapaiyan, Srinivasan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.