Using a compound to improve brain recovery after a lack of oxygen
Using NAD+ precursor for treatment of global cerebral ischemia
This study is looking at whether a supplement called NMN can help people recover from brain injuries caused by things like heart attacks or strokes by boosting energy in brain cells and protecting them from damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11118949 on NIH RePORTER |
What this research studies
This research investigates the use of nicotinamide mononucleotide (NMN) to treat brain injuries caused by conditions like cardiac arrest or stroke. The approach focuses on restoring cellular energy levels and improving mitochondrial function, which are critical for brain recovery. By administering NMN after ischemic events, the study aims to reduce brain damage and enhance neuroprotection through various cellular mechanisms. Patients may benefit from a treatment that targets multiple pathways involved in brain injury recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered from acute brain injuries due to cardiac arrest or stroke.
Not a fit: Patients with brain injuries not related to ischemic events may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that significantly reduces brain damage and improves recovery for patients who have experienced ischemic events.
How similar studies have performed: Previous studies have shown promising results with NMN in improving outcomes after ischemic brain injuries, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Kristian, Tibor — University of Maryland Baltimore
- Study coordinator: Kristian, Tibor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.