Using a brain fluid biomarker to monitor a type of brain cancer.
Intracranial D-2-Hydroxyglutarate as a Monitoring Biomarker for IDH-mutant Glioma.
This study is looking at a substance called D-2-Hydroxyglutarate (D2-HG) in the fluid around your brain to see if it can help doctors keep track of how well treatment is working for young adults with a type of brain cancer called IDH-mutant gliomas, making it easier to personalize care and spot any return of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11036886 on NIH RePORTER |
What this research studies
This research investigates the use of D-2-Hydroxyglutarate (D2-HG) as a biomarker to monitor the progression of IDH-mutant gliomas, a common type of brain cancer in young adults. The study aims to develop a reliable method for tracking the disease through cerebrospinal fluid (CSF) samples collected during routine clinical procedures. By analyzing the levels of D2-HG in the CSF, researchers hope to better understand how well patients are responding to treatments and to detect any recurrence of the disease. This approach could lead to more personalized and effective treatment strategies for patients with this challenging condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults diagnosed with IDH-mutant gliomas who are undergoing treatment.
Not a fit: Patients with other types of brain tumors or those who do not have IDH mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new way to monitor treatment responses and disease progression in patients with IDH-mutant gliomas.
How similar studies have performed: Previous research has shown promise in using biomarkers for monitoring cancer progression, suggesting that this approach could be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Burns, Terry — Mayo Clinic Rochester
- Study coordinator: Burns, Terry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.