Using 3D organoid models to understand how breast cancer progresses
Three-dimensional organoid models to study breast cancer progression
['FUNDING_R37'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10928084
This study is creating special 3D models of breast tissue to better understand how early-stage breast cancer, called DCIS, can turn into more serious forms, with the goal of finding new ways to stop this progression.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10928084 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative three-dimensional organoid models to study the progression of pre-invasive breast cancer, specifically Ductal Carcinoma in situ (DCIS), to invasive forms. By mimicking the tumor microenvironment, the study aims to investigate how factors like hypoxia and metabolic stress contribute to the transition from DCIS to more aggressive Invasive Ductal Carcinoma (IDC). The organoid models will allow researchers to observe tumor behavior in real-time, providing insights into the mechanisms driving cancer progression. This approach seeks to identify potential therapeutic targets to halt the progression of DCIS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Ductal Carcinoma in situ (DCIS) who are at risk of progression to invasive breast cancer.
Not a fit: Patients with invasive breast cancer or those without a diagnosis of DCIS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prognostic tools and treatments for patients with DCIS, potentially preventing the progression to invasive breast cancer.
How similar studies have performed: Previous research has shown promise in using organoid models to study cancer progression, indicating that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANT, SHILPA — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: SANT, SHILPA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.