Using 3D cultures of urine-derived stem cells to assess drug toxicity
3D Culture Systems Of Urine-Derived Stem Cell For NTRI-Induced Mitotoxicity Assessment
This study is looking at how safe HIV treatments are over the long run by using special 3D models made from urine-derived stem cells to better understand any potential side effects, so we can make sure patients stay safe while taking their medications.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10214526 on NIH RePORTER |
What this research studies
This research investigates the long-term safety of antiretroviral therapies (ART) used in HIV treatment by developing advanced 3D culture systems of urine-derived stem cells. These systems aim to provide a more accurate assessment of mitochondrial toxicity caused by ART compared to traditional 2D cultures, which often fail to predict long-term effects. By utilizing these innovative models, the research seeks to improve the predictive power of toxicity screening for antiviral drugs, ultimately enhancing patient safety. The study will involve evaluating how these 3D cultures respond to various ART compounds over extended periods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently receiving or considering antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer antiretroviral therapies with fewer long-term side effects for patients living with HIV.
How similar studies have performed: While traditional 2D culture systems have been widely used, this approach of using 3D cultures for assessing drug toxicity is relatively novel and has not been extensively tested in this context.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Zhang, Yuanyuan No — Wake Forest University Health Sciences
- Study coordinator: Zhang, Yuanyuan No
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.