USC cirrhosis center following people with compensated cirrhosis and portal hypertension
USC Cirrhosis Clinical Center
This project follows adults with compensated cirrhosis and clinically significant portal hypertension to learn how their health, tests, scans, and genes change over time and who might benefit from treatments like statins.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11169761 on NIH RePORTER |
What this research studies
You would join a group of about 2,000 people with compensated cirrhosis and clinically significant portal hypertension. Doctors and study staff will collect medical history, lifestyle information, blood tests, imaging, and store biospecimens for future lab studies. Participants will have regular clinic visits and active follow-up to track disease progression, complications, and outcomes. The study will also look at genetic factors (for example PNPLA3) and how medications such as statins relate to portal pressure and survival.
Who could benefit from this research
Good fit: Adults with compensated cirrhosis and clinically significant portal hypertension (CSPH), including those with cirrhosis from alcohol, viral hepatitis, or NASH, are the ideal candidates.
Not a fit: People with decompensated cirrhosis (those already having complications like ascites or variceal bleeding), children, or individuals without portal hypertension are unlikely to gain direct benefit from this cohort.
Why it matters
Potential benefit: If successful, this work could help predict who with compensated cirrhosis is most likely to worsen and point to treatments, including statins, that reduce portal pressure and liver-related deaths.
How similar studies have performed: Smaller prior studies suggest statins can lower portal pressure and may improve survival, but larger prospective cohorts like this are needed to confirm those findings and identify who benefits.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Terrault, Norah a. — University of Southern California
- Study coordinator: Terrault, Norah a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.