USC Alzheimer's participant and biomarker program
Clinical Core
Follows people at risk for Alzheimer's—especially those with the APOE ε4 gene—using exams, blood tests, and brain scans to track changes over time.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11382459 on NIH RePORTER |
What this research studies
You can join a program that enrolls people at risk for Alzheimer’s and follows them over time. The team collects medical history, cognitive testing, blood and other fluid samples, and brain imaging, and may ask for permission for brain donation after death. They keep a registry of 'study-ready' people and help match participants to other local and national studies and clinical trials. The program looks at how vascular and metabolic health and the APOE ε4 gene affect Alzheimer’s-related biomarkers and memory changes.
Who could benefit from this research
Good fit: Ideal candidates are older adults or people worried about memory loss, especially those who carry or may carry the APOE ε4 gene or who have vascular/metabolic risk factors, and who can attend regular visits at USC.
Not a fit: People without Alzheimer’s risk, those unwilling to undergo testing or follow-up visits, or those looking for immediate treatment are unlikely to get direct medical benefit from joining.
Why it matters
Potential benefit: If successful, this could speed up better ways to predict who will develop Alzheimer’s and connect patients to targeted prevention studies and trials.
How similar studies have performed: Long-running efforts like ADNI, DIAN, and A4 have successfully used similar registry, biomarker, and imaging approaches to improve diagnosis and prepare participants for trials.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Schneider, Lon S — University of Southern California
- Study coordinator: Schneider, Lon S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.