Urine marker panel for obstructive sleep apnea in children
UroMarker Test Panel for Obstructive Sleep Apnea
A non-invasive urine panel that looks for protein markers to help detect obstructive sleep apnea in children.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pgxl Technologies, LLC NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11330126 on NIH RePORTER |
What this research studies
If my child snores or has breathing pauses during sleep, this project uses a simple urine sample to look for a set of biomarkers linked to pediatric OSA. PGXL is developing a multiplexed immunoassay that measures several proteins in urine to screen for OSA and potentially monitor treatment response. The company plans to collect samples from children (about 0–11 years) and compare urine results to standard clinical tests like sleep studies. The goal is a CLIA-compatible, easier, and faster screening option than overnight polysomnography.
Who could benefit from this research
Good fit: Children aged 0–11 who snore, have suspected sleep-disordered breathing, daytime symptoms, or are being evaluated for possible OSA.
Not a fit: Adults, children without symptoms of sleep-disordered breathing, or patients who need a definitive overnight polysomnography for diagnosis may not benefit from this screening test.
Why it matters
Potential benefit: Could make screening and monitoring for pediatric OSA quicker, less invasive, and more accessible by using urine samples.
How similar studies have performed: Some biomarker research for OSA exists, but urine-based multiplex immunoassays for pediatric OSA are relatively new and not yet widely validated.
Where this research is happening
Louisville, United States
- Pgxl Technologies, LLC — Louisville, United States (Active)
Researchers
- Principal investigator: Burns, Christopher Thomas — Pgxl Technologies, LLC
- Study coordinator: Burns, Christopher Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.