Upgrading a specialized spectrometer for studying proteins and enzymes
Upgrade of Bruker Time-domain EPR Spectrometer
['FUNDING_OTHER'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10431412
This study is working on upgrading a special machine that helps scientists look closely at proteins and enzymes, which are important for understanding how our bodies work, and while it’s not directly for patients, the discoveries could help improve new medicines and treatments in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10431412 on ClinicalTrials.gov |
What this research studies
This project focuses on enhancing a Bruker time-domain electron paramagnetic resonance (EPR) spectrometer to improve its capabilities for studying the structure and function of proteins and enzymes at an atomic level. The upgrade will introduce advanced technologies that allow for more precise measurements and analysis of biochemical processes, particularly those involving metal centers and free radicals. By enabling experiments at lower protein concentrations and a wider range of temperatures, this research aims to provide deeper insights into the behavior of complex biological systems. Patients may benefit indirectly from the findings, as improved understanding of enzymes and proteins can lead to advancements in drug development and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions related to enzyme deficiencies or protein misfolding disorders.
Not a fit: Patients with conditions unrelated to enzyme or protein function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in the understanding and treatment of diseases related to enzyme and protein dysfunction.
How similar studies have performed: Other research has shown success with similar upgrades in spectroscopic techniques, enhancing our understanding of complex biological systems.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMIRNOV, ALEX I. — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: SMIRNOV, ALEX I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.