Understanding Your Alzheimer's Disease Path
Tau progression index (TPI): An individualized predictor of Alzheimer's Disease trajectory based on subject-specific connectomes
This project aims to create a personalized score that helps predict how Alzheimer's disease might progress for each individual.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11171411 on NIH RePORTER |
What this research studies
Alzheimer's disease affects everyone differently, and it can be hard to know how the disease will change over time. This project is developing a special score, called the Tau Progression Index (TPI), to give a clearer picture of what to expect. The TPI will use information from brain scans, including how different parts of the brain are connected and how certain proteins like amyloid and tau build up. This personalized information could help patients and their families better understand their unique journey with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates would be individuals with Alzheimer's disease or those at risk, who have undergone or are willing to undergo brain imaging and cognitive assessments.
Not a fit: Patients without Alzheimer's disease or related cognitive decline would not directly benefit from this specific prognostic tool.
Why it matters
Potential benefit: If successful, this tool could provide patients and their families with a more personalized understanding of their Alzheimer's disease progression, helping with future planning and treatment decisions.
How similar studies have performed: This project builds upon previous work by the research team and others, using established methods for analyzing brain connectivity and protein accumulation.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Razlighi, Qolamreza Ray — Weill Medical Coll of Cornell Univ
- Study coordinator: Razlighi, Qolamreza Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.